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By the time testosterone propionate leaves the body, testosterone phenylpropionate can already maintain the testosterone level in the bloodto levels associated with the male gender (5,9). In particular, we expect that in the long term, testosterone propionate, along with the active form of testosterone decanoate, will reduce the concentration of estradiol in the blood. The decrease in the estradiol concentration will contribute to a decrease in the total testosterone concentration.We hypothesized that, as a rule, a large difference in the levels of estradiol and testosterone was associated with low testosterone levels. In contrast, if it is determined that a male increases or decreases the estradiol concentration, he will decrease or increase the level or concentration of testosterone. Thus, the relationship between estradiol and male serum testosterone levels will be described in the linear order.To evaluate this hypothesis, we compared estradiol concentrations in serum samples taken during an oral testosterone injection to levels of testosterone in other serum samples. In the present study, we measured high and low testosterone levels. Our testosterone levels for all subjects were >2 ng/dL for the first time. This was found to be an unusual serum value in men. The mean blood testosterone of 15 healthy males was 7.8 ng/dL and the mean serum estradiol measured 3.9 μM. The mean serum serum estradiol of 7.7 μM for 14 obese subjects was 11.0 μM.The testosterone level in the low testosterone group was 6.5 ng/dL and for the low group it was 5.3 ng/dL and for the high group it was 3.8 ng/dL (Table 1). However, in men, the sex hormone-binding globulin (SHBG) level was >100 ng/dL in the low testosterone group and only <60 ng/dL in the high testosterone group (2,5,9). Estrogens have the important effect on the estradiol concentration in the blood, but SHBG is also a hormone that affects the circulating levels of cortisol. Thus, our testosterone levels in each group were significantly lower than the levels of testosterone in a single steroid.The high testosterone group had a mean serum testosterone level of 6.2 ng/dL and high testosterone level of 5.5 ng/dL when compared to all other men in the study, suggesting that it was a subgroup of those who have high testosterone concentrations (Figure 1).The low testosterone group had a mean serum testosterone level of 5.0 ng/dL and the mean serum serum estradiol level was 8.Related Article: